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Invitrogen
HSPA1A Recombinant Rabbit Monoclonal Antibody (24GB3205)
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FIGURE: 1 / 3
HSPA1A Antibody (MA5-57039) in ICC/IF
Immunocytochemical staining of HSPA1A in HepG2 cells using HSPA1A Recombinant Monoclonal Antibody (Product # MA5-57039) at a 1:1,1000 dilution. Nuclei were stained blue with DAPI; Hsp70 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-57039
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
24GB3205
Immunogen
A synthesized peptide derived from human Hsp70 (aa 400-641)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.8 mg/mL
Amount
80 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 68 kDa heat shock protein; Heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; Heat shock 70 kDa protein 3; heat shock 70kDa protein 1A; heat shock protein 70-1; Heat shock protein family A member 1A; Heat shock protein family A member 1B; heat shock protein, 70 kDa 3; Hsp68; HSP70-1; HSP70-1/HSP70-2; HSP70-2; HSP70.1/2; HSP70.1/HSP70.2; HSP70.3; inducible heat shock protein 70
Gene Aliases: hsp68; Hsp70-1; Hsp70-2; Hsp70-3; Hsp70.3; Hsp70A1; HSP72; HSPA1; HSPA1A; HSPA1B; Hspa2; HSX70
UniProt ID: (Mouse) Q61696, (Rat) P0DMW0
Entrez Gene ID: (Mouse) 193740, (Rat) 24472
G-protein coupled receptor binding
protease binding
double-stranded RNA binding
ATP binding
ATPase activity
enzyme binding
heat shock protein binding
ubiquitin protein ligase binding
ATPase activity, coupled
protein binding involved in protein folding
poly(A) RNA binding
protein N-terminus binding
NF-kappaB binding
unfolded protein binding
C3HC4-type RING finger domain binding
protein binding
telomere maintenance
DNA repair
protein folding
response to heat
positive regulation of T cell mediated cytotoxicity
mRNA catabolic process
defense response
response to unfolded protein
binding of sperm to zona pellucida
negative regulation of cell proliferation
regulation of cell death
negative regulation of cell growth
negative regulation of protein ubiquitination
negative regulation of myeloid cell apoptotic process
cellular response to heat
protein refolding
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of erythrocyte differentiation
negative regulation of vasoconstriction
negative regulation of cell death
cellular heat acclimation
negative regulation of inclusion body assembly
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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