Search
Invitrogen
CD299 (DC-SIGN/L) Recombinant Rabbit Monoclonal Antibody (4O9A4)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 2
CD299 (DC-SIGN/L) Antibody (MA5-58219) in ICC/IF
Immunocytochemistry analysis of CD299 (DC-SIGN/L) using 293T cells. The cells were incubated using 1:200 dilution with CD299 (DC-SIGN/L) Recombinant Monoclonal Antibody (Product # MA5-58220) (100x lens). Followed by further incubation with Cy3-conjugated Goat anti-Rabbit IgG (H+L) using a 1:500 dilution (Red). DAPI was used for nuclear staining (Blue).
Product Details
MA5-58219
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4O9A4
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 71-399 of human DC-SIGNR/CD299 (NP_055072.3).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.257 mg/mL
Amount
5.14 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
Immunogen sequence: QVSKVPSSLS QEQSEQDAIY QNLTQLKAAV GELSEKSKLQ EIYQELTQLK AAVGELPEKS KLQEIYQELT RLKAAVGELP EKSKLQEIYQ ELTRLKAAVG ELPEKSKLQE IYQELTRLKA AVGELPEKSK LQEIYQELTE LKAAVGELPE KSKLQEIYQE LTQLKAAVGE LPDQSKQQQI YQELTDLKTA FERLCRHCPK DWTFFQGNCY FMSNSQRNWH DSVTACQEVR AQLVVIKTAE EQNFLQLQTS RSNRFSWMGL SDLNQEGTWQ WVDGSPLSPS FQRYWNSGEP NNSGNEDCAE FSGSGWNDNR CDVDNYWICK KPAACFRDE
Target Information
CLEC4M is a type II integral membrane protein that is 77% identical to CD209 antigen, a HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes a type II integral membrane protein that is 77% identical to CD209 antigen, a HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: C-type lectin; C-type lectin domain family 4 member M; CD209 antigen-like protein 1; CD209b antigen; CD299; CD299 antigen; DC-SIGN-related protein; DC-SIGN2; DC-SIGNR; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; L-SIGN; liver/lymph node-specific ICAM-3 grabbing non-integrin; Liver/lymph node-specific ICAM-3-grabbing non-integrin; mannose binding C-type lectin DC-SIGNR; MGC129964; MGC47866; type II integral membrane protein; unnamed protein product
Gene Aliases: CD209L; CD209L1; CD299; CLEC4M; DC-SIGN2; DC-SIGNR; DCSIGNR; HP10347; L-SIGN; LSIGN
UniProt ID: (Human) Q9H2X3
Entrez Gene ID: (Human) 10332, (Rat) 288378
virus receptor activity
protein binding
mannose binding
carbohydrate binding
ICAM-3 receptor activity
signaling receptor activity
pattern recognition receptor activity
peptide antigen binding
virion binding
metal ion binding
calcium-dependent protein binding
(1->3)-beta-D-glucan binding
polysaccharide binding
membrane traffic protein
adaptive immune response
immune system process
endocytosis
immune response
leukocyte cell-cell adhesion
cell-cell recognition
virion attachment to host cell
receptor-mediated endocytosis of virus by host cell
viral genome replication
antigen processing and presentation
intracellular signal transduction
innate immune response
viral entry into host cell
receptor-mediated virion attachment to host cell
peptide antigen transport
intracellular transport of virus
detection of yeast
phagocytosis, recognition
regulation of gene expression
detection of bacterium
regulation of blood coagulation
positive regulation of tumor necrosis factor biosynthetic process
positive regulation of phagocytosis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support