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Invitrogen
KIR2DL1/2/3 (Lirilumab Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA5-58345
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG4SP
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
KIR2DL1 gene encodes a myotubularin-related protein. The encoded protein is a phosphoinositide phosphatase that specifically dephosphorylates phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 3-phosphate. Mutations in this gene are correlated with autosomal dominant centronuclear myopathy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 18. KIR2DL2 and KIR2DL3 are genes belonging to the killer cell immunoglobulin-like receptor (KIR) family, located on chromosome 19q13.4. They encode inhibitory receptors expressed primarily on natural killer (NK) cells and a subset of T cells. The proteins produced by these genes play a key role in regulating the immune response through their interaction with human leukocyte antigen (HLA) class I molecules, specifically HLA-C alleles. KIR2DL2 recognizes a broad range of HLA-C alleles with a lysine at position 80 (C1 group), while KIR2DL3 has a higher affinity for the HLA-C1 group. Structurally, these receptors consist of two extracellular immunoglobulin-like domains, a transmembrane region, and a long cytoplasmic tail that contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Upon ligand binding, these receptors transmit inhibitory signals to prevent NK cell activation, thereby protecting healthy cells from immune destruction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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