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Invitrogen
CGRPR (Erenumab Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA5-58829
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG2SA, lambda
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
The Calcitonin Gene-Related Peptide Receptor (CGRPR) primarily refers to the receptor complex involving the gene CALCRL (calcitonin receptor-like receptor) and the receptor activity-modifying protein (RAMP1). This complex is vital in the transmission of signals for the peptide hormone calcitonin gene-related peptide (CGRP). CALCRL is located on chromosome 2 and is part of the G protein-coupled receptor family. The functional receptor is significant in mediating vascular smooth muscle cell relaxation and is thus involved in various physiological responses, including vasodilation, pain transmission, and neurogenic inflammation. The receptor’s activation by CGRP plays an essential role in migraine pathophysiology by promoting vasodilation and influencing pain signaling pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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