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Invitrogen
CD47 (Lemzoparlimab Biosimilar) Recombinant Human Monoclonal Antibody
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CD47 (Lemzoparlimab Biosimilar) Antibody (MA5-59460) in Flow
Flow cytometry analysis of CD47 (Lemzoparlimab Biosimilar) Recombinant monoclonal antibody (Product # MA5-59459). PANC-1 cells were stained with (lemzoparlimab) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50=0.265 µg/mL.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-59460
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG4
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
1 mg/mL
规格
1 mg
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
CD47, known as integrin-associated protein (IAP), is a glycosylated transmembrane glycoprotein with five domains, expressed widely across hematopoietic cells like T and B cells, monocytes, platelets, and erythrocytes, as well as non-hematopoietic cells. It interacts with integrins such as CD51/CD61 and CD41/CD61, and serves as a receptor for thrombospondin, mediating bi-directional signaling that affects neural synaptic activity and macrophage phagocytosis. CD47 acts as a ligand for CD172a (SIRP alpha), an inhibitory receptor on macrophages, preventing phagocytosis of CD47-positive cells. This interaction influences cell migration, B cell adhesion, T cell activation, and neuronal development, particularly in synapse-rich brain and retina regions. It also modulates chondrocyte responses to mechanical signals. T cell expression of CD47 can lead to activation or apoptosis in the presence of thrombospondin. Monoclonal antibody stimulation of CD47 has been shown to induce CD4+CD25- suppressive activity and increase Foxp3 expression. CD47's role in membrane transport, signal transduction, and its broad tissue distribution highlight its significance in various physiological processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Antigenic surface determinant protein OA3; CD47; CD47 antigen; IAP; Integrin-associated protein; Leukocyte surface antigen CD47; Protein MER6; sCD47; soluble CD 47; soluble CD47
基因别名: CD47; MER6
Entrez Gene ID: (Human) 961
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
