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Invitrogen
IL-1 alpha/beta (Lutikizumab Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA5-60125
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
IL-1a (Interleukin-1 alpha) is a proinflammatory cytokine produced mainly by monocytes, macrophages, and dendritic cells. Encoded by the IL1A gene on chromosome 2q13, it signals through IL-1RI and IL-1RII receptors, which are shared with IL-1B. IL-1a plays a key role in innate immunity by inducing other proinflammatory cytokines and initiating acute-phase responses. It regulates NF-kB and MAPK pathways and stimulates expression of IL-6, COX-2, and nitric oxide. IL-1a is synthesized as a proprotein that can be processed and released upon cell injury, contributing to inflammation and apoptosis. Its activity is controlled by IL-1 receptor antagonist (IL-1RA), which competitively blocks receptor binding. Elevated IL-1a levels are associated with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis. The IL1A gene is part of an interleukin-1 family gene cluster on chromosome 2.
IL-1b (Interleukin-1 beta) is another potent proinflammatory cytokine produced by similar immune cells. It is synthesized as an inactive 31 kDa precursor (pro-IL-1b) in response to inflammatory stimuli. Activation requires inflammasomes, which trigger caspase-1-mediated cleavage into the active 17 kDa form. Unlike many secreted proteins, IL-1b lacks a classical signal peptide and is released through nontraditional secretion pathways. IL-1b signals through IL-1RI and IL-1RII and is also regulated by IL-1RA. It promotes cytokine production and acute-phase responses during infection and tissue injury. Elevated IL-1b levels are linked to numerous chronic inflammatory conditions, and IL-1b-neutralizing therapies have important clinical applications.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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