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Invitrogen
GATA2 Recombinant Rabbit Monoclonal Antibody (PSH04-53)
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图: 1 / 8
GATA2 Antibody (MA562900) in ICC/IF
Immunofluorescence analysis of GATA2 using SH-SY5Y (positive) and Jurkat (negative). The cells were fixed in 4% paraformaldehyde for 20 minutes at room temperature, permeabilized with 0.1% Triton X-100 in PBS for 5 minutes at room temperature, then blocked with 1% BSA in 10% negative goat serum for 1 hour at room temperature. The cells were co-labeled with GATA2 Recombinant Rabbit Monoclonal Antibody (PSH04-53) (Product # MA562900) (green) and beta tubulin (red) at 1:100 dilution in 1% BSA in PBST overnight at 4 degrees Celsius and then wi... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA562900
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH04-53
抗原
Synthetic peptide within human GATA2 aa 1-50.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: SH-SY5Y cell lysate, LNCaP cell lysate, PC-12 cell lysate, SH-SY5Y.
Tissue Specificity: Low tissue specificity.
Subcellular Location: SH-SY5Y cell lysate, LNCaP cell lysate, PC-12 cell lysate, SH-SY5Y.
Sequence Similarities: 100% Mouse/Rat.
Predicted band size: 51 kDa.
靶标信息
GATA2 (GATA binding protein 2) belongs to the GATA family of transcription factors. GATA proteins play a very important role in signaling pathways controlling proliferation and differentiation of erythroid progenitor cells. There are 6 transcription factors in the GATA family: GATA1 to GATA6. GATA2 is a transcriptional activator regulating endothelin-1 gene expression in endothelial cells. It also appears to be involved in differentiation of other tissue types (uro-genital and nervous) during embryogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Endothelial transcription factor GATA-2; FLJ45948; GATA-binding protein 2; GATA-bindning protein 2; gata2 {ECO:0000312|EMBL:AAK51128.1}; MGC2306
基因别名: GATA2
UniProt ID: (Rat) Q924Y4
Entrez Gene ID: (Rat) 25159
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
enhancer sequence-specific DNA binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
zinc ion binding
sequence-specific DNA binding
C2H2 zinc finger domain binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
urogenital system development
cell fate determination
neuron migration
embryonic placenta development
transcription, DNA-templated
transcription from RNA polymerase II promoter
phagocytosis
positive regulation of cytosolic calcium ion concentration
ventral spinal cord interneuron differentiation
cell differentiation in hindbrain
commitment of neuronal cell to specific neuron type in forebrain
central nervous system neuron development
pituitary gland development
cell differentiation
neuron differentiation
response to lipid
somatic stem cell population maintenance
regulation of histone acetylation
eosinophil fate commitment
inner ear morphogenesis
mast cell degranulation
negative regulation of fat cell differentiation
negative regulation of myeloid cell differentiation
positive regulation of erythrocyte differentiation
negative regulation of macrophage differentiation
positive regulation of megakaryocyte differentiation
positive regulation of neuron differentiation
negative regulation of Notch signaling pathway
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
cell maturation
neuron fate commitment
homeostasis of number of cells within a tissue
positive regulation of phagocytosis
positive regulation of phagocytosis, engulfment
definitive hemopoiesis
semicircular canal development
negative regulation of fat cell proliferation
GABAergic neuron differentiation
negative regulation of neural precursor cell proliferation
regulation of forebrain neuron differentiation
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