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Positive Control: HepG2 cell lysate, Mouse heart tissue lysate, Mouse kidney tissue lysate, Rat heart tissue lysate, Rat liver tissue lysate, Rat brain tissue lysate, human brain tissue, human heart tissue, mouse brain tissue, mouse heart tissue, rat brain tissue, rat heart tissue.
Tissue Specificity: Tissue enhanced (heart muscle, skeletal muscle, tongue)
Subcellular Location: Mitochondrion inner membrane
Sequence Similarities: 85% Mouse/Rat
Predicted band size: 17 kDa
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: COX5A; Cytochrome c oxidase polypeptide Va; cytochrome c oxidase polypeptide, mitochondrial; Cytochrome c oxidase subunit 5A, mitochondrial; cytochrome c oxidase subunit Va; mitochondrial cytochrome c oxidase subunit Va
基因别名: AA959768; CcOX; COX; COX-VA; COX5A; MC4DN20; VA
UniProt ID: (Human) P20674, (Rat) P11240, (Mouse) P12787
Entrez Gene ID: (Human) 9377, (Rat) 252934, (Mouse) 12858