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Invitrogen
SIRT3 Monoclonal Antibody (C2)
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FIGURE: 1 / 6
SIRT3 Antibody (MA565970) in IHC (P)
Immunohistochemistry analysis of SIRT3 in paraffin-embedded Human Stomach tissue. Samples were incubated with SIRT3 Monoclonal (Product # MA565970) antibody using a dilution of 30 µg/mL, followed by HRP-Linked Caprine Anti-Mouse IgG (2 µg/mL) and DAB.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA565970
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
C2
Immunogen
Recombinant Sirtuin 3 (SIRT3) (Gln126-Lys399)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
200 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
SIRT3 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The SIRT3 is included in class I of the sirtuin family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HGNC:14931; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase; NAD-dependent deacetylase sirtuin-3, mitochondrial; NAD-dependent deacetylase; sirtuin 3 long reading frame; NAD-dependent protein delactylase sirtuin-3; regulatory protein SIR2 homolog 3; silent mating type information regulation 2, S.cerevisiae, homolog 3; sir2-like 3; SIR2-like protein 3; SIRT3L mitochondrial; sirtuin type 3; unnamed protein product; yeast silent information regulator 2 (Sir2p) homolog
Gene Aliases: SIR2L3
UniProt ID: (Human) Q9NTG7
Entrez Gene ID: (Human) 23410, (Rat) 293615
NAD+ ADP-ribosyltransferase activity
protein binding
zinc ion binding
transferase activity, transferring acyl groups other than amino-acyl groups
NAD-dependent histone deacetylase activity
enzyme binding
protein deacetylase activity
NAD-dependent protein deacetylase activity
sequence-specific DNA binding
NAD+ binding
NAD-dependent protein lysine delactylase activity
protein ADP-ribosylase activity
NAD-dependent histone deacetylase activity (H3-K14 specific)
chromatin remodeling
protein deacetylation
mitochondrial fusion
aerobic respiration
positive regulation of insulin secretion
cellular response to stress
peptidyl-lysine deacetylation
negative regulation of ERK1 and ERK2 cascade
positive regulation of superoxide dismutase activity
positive regulation of catalase activity
positive regulation of oxidative phosphorylation
positive regulation of ceramide biosynthetic process
negative regulation of reactive oxygen species metabolic process
positive regulation of transcription from mitochondrial promoter
negative regulation of peptidyl-lysine acetylation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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