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Invitrogen
Tigecycline Recombinant Mouse Monoclonal Antibody (1B9)
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FIGURE: 1 / 1
Tigecycline Antibody (MA566278) in SDS-PAGE
SDS-PAGE characterization of Tigecycline under reducing conditions. Lane M: Protein marker (kDa); Lane TGC: Purified Tigecycline Recombinant Monoclonal (Product # MA566278). Tigecycline showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-421.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA566278
Product Specifications
Species Reactivity
Chemical
Host/Isotype
Mouse
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1B9
Immunogen
Conjugate of TGC hapten and KLH.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.6 mg/mL
Amount
200 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Tigecycline is a semisynthetic antibiotic belonging to the glycylcycline class, developed to treat polymicrobial infections caused by multidrug-resistant Gram-positive and Gram-negative pathogens. It is designed to evade tetracycline resistance mechanisms, such as ribosomal protection and active drug efflux. Tigecycline functions by binding to the 30S ribosomal subunit, inhibiting protein synthesis in bacteria, which makes it effective against a wide range of bacterial infections. Despite its efficacy, the emergence of high-level tigecycline resistance, particularly mediated by plasmid-encoded genes like tet(X), poses a significant challenge to its clinical use. Strategies to overcome resistance include combining tigecycline with adjuvants like curcumin, which can reverse resistance mechanisms. Tigecycline is administered intravenously and is considered a last-resort antibiotic due to its broad-spectrum activity and ability to overcome resistance mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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