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Invitrogen
Spironolactone Recombinant Mouse Monoclonal Antibody (5A5)
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FIGURE: 1 / 1
Spironolactone Antibody (MA566309) in SDS-PAGE
SDS-PAGE characterization of Spironolactone under reducing conditions. Lane M: Protein marker (kDa); Lane CRN: Purified Spironolactone Recombinant Monoclonal (Product # MA566309). Spironolactone showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-649.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA566309
Product Specifications
Species Reactivity
Chemical
Host/Isotype
Mouse
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
5A5
Immunogen
Conjugate of CRN hapten and KLH.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
3.2 mg/mL
Amount
200 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Spironolactone is a synthetic steroid that functions as a potassium-sparing diuretic and antihypertensive agent, primarily used to treat conditions such as heart failure, hypertension, and certain cases of hyperaldosteronism. It works by antagonizing the action of aldosterone, a hormone that increases sodium reabsorption in the kidneys, thus promoting the excretion of sodium and water while retaining potassium. The molecular structure of spironolactone includes a lactone ring, which is crucial for its binding to the mineralocorticoid receptor. Spironolactone is metabolized in the liver, and its active metabolites contribute to its therapeutic effects. Recent studies have explored its topical application using polymeric nanoparticles for targeted delivery in treating conditions like acne and alopecia, enhancing its efficacy and safety profile. Bioequivalence studies have been conducted to compare different formulations of spironolactone, ensuring consistent therapeutic outcomes across various products.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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