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Invitrogen
Sibutramine Recombinant Mouse Monoclonal Antibody (3E11)
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图: 1 / 1
Sibutramine Antibody (MA566322) in SDS-PAGE
SDS-PAGE characterization of Sibutramine under reducing conditions. Lane M: Protein marker (kDa); Lane SBTM: Purified Sibutramine Recombinant Monoclonal (Product # MA566322). Sibutramine showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-631.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA566322
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3E11
抗原
Conjugate of SBTM hapten and KLH.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
4 mg/mL
规格
200 µg
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Sibutramine is a centrally acting antiobesity drug that functions primarily as a serotonin and noradrenaline reuptake inhibitor, enhancing satiety and potentially increasing energy expenditure. It is metabolized by cytochrome P450 enzymes, particularly CYP2B6, which catalyzes the formation of its active metabolites, desmethylsibutramine (M1) and didesmethylsibutramine (M2). Genetic polymorphisms in CYP2B6, CYP3A5, and CYP2C19 can influence the pharmacokinetics and clinical outcomes of sibutramine treatment, affecting weight loss efficacy and the occurrence of adverse events. Sibutramine is available in different formulations, such as sibutramine hydrochloride monohydrate and sibutramine mesylate hemihydrate, which may vary in solubility and absorption rates, impacting their pharmacological profiles.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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