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Invitrogen
Hemolysin BL A Recombinant Mouse Monoclonal Antibody (15C7)
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Hemolysin BL A Antibody (MA566467) in SDS-PAGE
SDS-PAGE characterization of Hemolysin BL A under reducing conditions. Lane M: Protein marker (kDa); Lane HBLA-D: Purified Hemolysin BL A Recombinant Monoclonal (Product # MA566467). Hemolysin BL A showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-323.
产品信息
MA566467
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
15C7
抗原
Hemolysin BL A.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
5.2 mg/mL
规格
200 µg
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Hemolysin BL (HBL) is a tripartite toxin produced by Bacillus cereus, consisting of three distinct proteins: B, L1, and L2. These components work synergistically to exhibit hemolytic, cytotoxic, and dermonecrotic activities, contributing to its role as a virulence factor in foodborne diarrheal illnesses. The toxin operates by forming pores in cell membranes, leading to cell lysis and fluid accumulation, as demonstrated in ligated rabbit ileal loop assays. The gene encoding Hemolysin BL is located within the Bacillus cereus genome, and its expression is tightly regulated to ensure effective pathogenicity. Structural studies have provided insights into the assembly of the HBL complex, revealing the intricate interactions between its subunits, which are crucial for its functionality.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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