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Invitrogen
CD3e/CD3g Recombinant Rabbit Monoclonal Antibody (4F5G4)
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CD3e/CD3g Antibody (MA568571) in WB
Western blot analysis of CD3e/CD3g in various lysates. Samples were incubated with CD3e/CD3g Monoclonal antibody (Product # MA5-42744) using a dilution of 1:2,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA568571
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
4F5G4
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-207(CD3E)& 1-182(CD3G) of human CD3 epsilon&CD3 gamma Heterodimer
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.0 mg/mL
规格
20 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
The target is usually found in the following locations: Cell membrane, Single-pass type I membrane protein, Membrane, Single-pass type I membrane protein.
Immunogen sequence: MQSGTHWRVL GLCLLSVGVW GQDGNEEMGG ITQTPYKVSI SGTTVILTCP QYPGSEILWQ HNDKNIGGDE DDKNIGSDED HLSLKEFSEL EQSGYYVCYP RGSKPEDANF YLYLRARVCE NCMEMDVMSV ATIVIVDICI TGGLLLLVYY WSKNRKAKAK PVTRGAGAGG RQRGQNKERP PPVPNPDYEP IRKGQRDLYS GLNQRRI(CD 3E)&MEQGKG LAVLILAIIL LQGTLAQSIK GNHLVKVYDY QEDGSVLLTC DAEAKNITWF KDGKMIGFLT EDKKKWNLGS NAKDPRGMYQ CKGSQNKSKP LQVYYRMCQN CIELNAATIS GFLFAEIVSI FVLAVGVYFI AGQDGVRQSR ASDKQTLLPN DQLYQPLKDR EDDQYSHLQG NQLRRN(CD3 G)
靶标信息
The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD3e; CD3g; T-cell receptor T3 gamma chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain
基因别名: CD3E; CD3G; T3E; T3G
Entrez Gene ID: (Human) 916, (Human) 917
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