Search
Invitrogen
CHI3L1 Recombinant Rabbit Monoclonal Antibody (7T1R3)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
MA568589
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
7T1R3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 284-383 of human YKL-40/CHI3L1 (NP_001267.2).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
20 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunogen sequence: PGRFTKEAGT LAYYEICDFL RGATVHRILG QQVPYATKGN QWVGYDDQES VKSKVQYLKD RQLAGAMVWA LDLDDFQGSF CGQDLRFPLT NAIKDALAAT
Target Information
Human cartilage glycoprotein 39 (GP-39), also known as YKL-40, is a glycoprotein secreted by articular chondrocytes, synoviocytes and macrophages. Serum and synovial fluid GP-39 levels are elevated in inflammatory diseases and correlate with the degree of joint destruction in rheumatoid arthritis. GP-39 is expressed in articular chondrocytes and synovial cells, as well as in liver, but is undetectable in muscle tissues, lung, pancreas, mononuclear cells and fibroblasts. GP-39 is a candidate autoantigen in rheumatoid arthritis and is important in the capacity of cells to respond to and cope with changes in their environment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: 39 kDa synovial protein; Breast regression protein 39; BRP39 protein; Cartilage glycoprotein 39; CGP-39; CGP39; Chitinase 3 like protein 1CGP 39; chitinase 3-like 1; chitinase 3-like 1 (cartilage glycoprotein-39); Chitinase-3-like protein 1; DKFZp686N19119; FLJ38139; GP-39; hCGP39; unnamed protein product; YKL-40
Gene Aliases: ASRT7; AW208766; Brp39; CGP-39; CHI3L1; Chil1; GP-39; GP39; HC-gp39; hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40
UniProt ID: (Human) P36222, (Mouse) Q61362
Entrez Gene ID: (Human) 1116, (Mouse) 12654
carbohydrate metabolic process
chitin catabolic process
apoptotic process
inflammatory response
activation of NF-kappaB-inducing kinase activity
response to mechanical stimulus
positive regulation of peptidyl-threonine phosphorylation
lung development
positive regulation of interleukin-8 production
response to tumor necrosis factor
positive regulation of angiogenesis
cartilage development
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
response to interleukin-1
response to interleukin-6
cellular response to tumor necrosis factor
interleukin-8 secretion
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support