Search

  • Contact Us
  • Quick Order

Invitrogen

SMAD3 Recombinant Rabbit Monoclonal Antibody (5W8U8)

View all (59) SMAD3 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
SMAD3 Recombinant Rabbit Monoclonal Antibody (5W8U8)

Product Details

MA568749

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:20,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

5W8U8

Immunogen

Synthetic peptide
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.1 mg/mL

Amount

22 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Immunogen sequence: HHELRAMELC EFAFNMKKDE VCVNPYHYQR VETPVLPPVL VPRHTEIPAE FPPLDDYSHS IPENTNFPAG IEPQSNIPET PPPGYLSEDG ETSDHQMNHS M

Target Information

SMAD3 belongs to the SMAD family of proteins. They are similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: DKFZp586N0721; DKFZp686J10186; JV15-2; MAD (mothers against decapentaplegic, Drosophila) homolog 3; MAD homolog 3; MAD-3; mad3; MGC60396; mMad3; Mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; SMAD; SMAD 3; SMAD family member 3

View more View less

Gene Aliases: AU022421; mad3; MADH3; Smad 3; SMAD3

View more View less

UniProt ID: (Mouse) Q8BUN5, (Rat) P84025

View more View less

Entrez Gene ID: (Mouse) 17127, (Rat) 25631

View more View less

Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter sequence-specific core promoter proximal region sequence-specific DNA binding transcription factor activity, protein binding RNA polymerase II activating transcription factor binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transforming growth factor beta receptor binding protein binding collagen binding beta-catenin binding transcription factor binding zinc ion binding enzyme binding protein kinase binding phosphatase binding transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity chromatin DNA binding ubiquitin protein ligase binding identical protein binding protein homodimerization activity ubiquitin binding bHLH transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding SMAD binding metal ion binding protein heterodimerization activity co-SMAD binding R-SMAD binding DNA-binding transcription factor gene-specific transcriptional regulator
Process(es)
negative regulation of transcription from RNA polymerase II promoter skeletal system development osteoblast differentiation response to hypoxia in utero embryonic development mesoderm formation somitogenesis liver development negative regulation of protein phosphorylation heart looping osteoblast development immune system development transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transport activation of cysteine-type endopeptidase activity involved in apoptotic process immune response cell cycle arrest transforming growth factor beta receptor signaling pathway SMAD protein complex assembly gastrulation endoderm development negative regulation of cell proliferation embryonic pattern specification positive regulation of gene expression positive regulation of alkaline phosphatase activity positive regulation of epithelial to mesenchymal transition regulation of striated muscle tissue development regulation of transforming growth factor beta receptor signaling pathway evasion or tolerance of host defenses by virus signal transduction involved in regulation of gene expression negative regulation of cell growth positive regulation of cell migration positive regulation of bone mineralization thyroid gland development positive regulation of chondrocyte differentiation positive regulation of interleukin-1 beta production regulation of transforming growth factor beta2 production positive regulation of transforming growth factor beta3 production activin receptor signaling pathway negative regulation of osteoblast proliferation positive regulation of catenin import into nucleus intracellular signal transduction nodal signaling pathway T cell activation negative regulation of protein catabolic process positive regulation of transcription factor import into nucleus negative regulation of apoptotic process cell-cell junction organization negative regulation of osteoblast differentiation positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter paraxial mesoderm morphogenesis developmental growth embryonic foregut morphogenesis embryonic cranial skeleton morphogenesis regulation of epithelial cell proliferation negative regulation of inflammatory response regulation of immune response protein stabilization positive regulation of positive chemotaxis regulation of binding positive regulation of stress fiber assembly positive regulation of focal adhesion assembly pericardium development transdifferentiation SMAD protein signal transduction negative regulation of wound healing lens fiber cell differentiation positive regulation of canonical Wnt signaling pathway extrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of extracellular matrix assembly ureteric bud development
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support