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Invitrogen
PI3K p85 Recombinant Rabbit Monoclonal Antibody (7W7L10)
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PI3K p85 Antibody (MA568871) in WB
Western Blot analysis of various lysates using PI3K p85 Recombinant Monoclonal Antibody (Product # MA5-55523) at 1:3,000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1:10,000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA568871
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
7W7L10
抗原
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human PI3 Kinase p85 alpha/beta.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.32 mg/mL
规格
6.4 µg
纯化类型
Protein A
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunogen Sequence: SVVELINHYR NESLAQYNPK LDVKLLYPVS KYQQDQVVKE DNIEAVGKKL HEYNTQFQEK SREYDRLYEE YTRTSQEIQM KRTAIEAFNE TIKIFEEQCQ T
靶标信息
Phosphatidylinositol 3-kinase (PIK3) is a signaling protein that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Signaling is initiated when upstream tyrosine kinase receptors or G protein coupled receptors are bound by their ligands. It binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. During insulin stimulation, it also binds to IRS-1. Mutations in the gene can result in Agammaglobulinemia 7, SHORT syndrome, or Immunodeficiency 36.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; Phosphatidylinositol 3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit beta; PI3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-alpha; PI3-kinase subunit p85-beta; PI3K regulatory subunit alpha; PI3K regulatory subunit beta; ptdIns-3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory subunit p85-beta
基因别名: GRB1; p50alpha; p55alpha; p85alpha; p85beta; PI3K; PIK3R1; PIK3R2
UniProt ID: (Mouse) P26450, (Mouse) O08908
Entrez Gene ID: (Mouse) 18708, (Mouse) 18709
receptor binding
insulin receptor binding
insulin-like growth factor receptor binding
platelet-derived growth factor receptor binding
neurotrophin TRKA receptor binding
protein binding
calmodulin binding
protein C-terminus binding
transcription factor binding
1-phosphatidylinositol-3-kinase activity
protein kinase binding
protein phosphatase binding
protein domain specific binding
estrogen receptor binding
receptor tyrosine kinase binding
ubiquitin protein ligase binding
phosphatidylinositol 3-kinase regulator activity
phosphatidylinositol 3-kinase regulatory subunit binding
ErbB-3 class receptor binding
phosphatidylinositol 3-kinase binding
insulin binding
insulin receptor substrate binding
1-phosphatidylinositol-3-kinase regulator activity
protein heterodimerization activity
ATPase binding
phosphoprotein binding
kinase modulator
cellular glucose homeostasis
positive regulation of protein phosphorylation
negative regulation of cell-matrix adhesion
glucose metabolic process
protein phosphorylation
transport
negative regulation of cell adhesion
signal transduction
insulin receptor signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of heart rate
positive regulation of gene expression
negative regulation of muscle cell apoptotic process
phosphatidylinositol 3-kinase signaling
protein transport
negative regulation of cell-cell adhesion
B cell differentiation
positive regulation of cell migration
positive regulation of tumor necrosis factor production
response to insulin
cellular response to insulin stimulus
positive regulation of RNA splicing
cellular response to UV
response to endoplasmic reticulum stress
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of transcription factor import into nucleus
negative regulation of apoptotic process
regulation of phosphatidylinositol 3-kinase activity
positive regulation of myoblast differentiation
negative regulation of osteoclast differentiation
negative regulation of blood pressure
negative regulation of proteolysis
positive regulation of transcription from RNA polymerase II promoter
phosphatidylinositol phosphorylation
insulin-like growth factor receptor signaling pathway
negative regulation of smooth muscle cell proliferation
protein stabilization
response to glucocorticoid
regulation of stress fiber assembly
NFAT protein import into nucleus
response to cAMP
growth hormone receptor signaling pathway
regulation of establishment of protein localization to plasma membrane
positive regulation of endoplasmic reticulum unfolded protein response
regulation of autophagy
regulation of actin filament polymerization
regulation of phosphorylation
positive regulation of cell adhesion
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