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Invitrogen
KIR2DL2/KIR2DL3 Recombinant Rabbit Monoclonal Antibody (6W7Q7)
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图: 1 / 7
KIR2DL2/KIR2DL3 Antibody (MA569290) in ICC/IF
Immunocytochemical analysis of KIR2DL2/KIR2DL3 in 293F-KIR2DL3 and 293F cells. Samples were incubated with KIR2DL2/KIR2DL3 recombinant monoclonal antibody (Product # MA569290) using a dilution of 1:200 (40x lens). DAPI was used for nuclear staining (Blue).
产品信息
MA569290
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
6W7Q7
抗原
Recombinant protein (or fragment).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.09 mg/mL
规格
109 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3., with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
KIR2DL2 and KIR2DL3 are genes belonging to the killer cell immunoglobulin-like receptor (KIR) family, located on chromosome 19q13.4. They encode inhibitory receptors expressed primarily on natural killer (NK) cells and a subset of T cells. The proteins produced by these genes play a key role in regulating the immune response through their interaction with human leukocyte antigen (HLA) class I molecules, specifically HLA-C alleles. KIR2DL2 recognizes a broad range of HLA-C alleles with a lysine at position 80 (C1 group), while KIR2DL3 has a higher affinity for the HLA-C1 group. Structurally, these receptors consist of two extracellular immunoglobulin-like domains, a transmembrane region, and a long cytoplasmic tail that contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Upon ligand binding, these receptors transmit inhibitory signals to prevent NK cell activation, thereby protecting healthy cells from immune destruction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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