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Invitrogen
Claudin 3 Recombinant Rabbit Monoclonal Antibody (1N7C6)
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FIGURE: 1 / 8
Claudin 3 Antibody (MA569293) in ICC/IF
Immunocytochemical analysis of Claudin 3 in T-47D cells. Samples were incubated with Claudin 3 recombinant monoclonal antibody (Product # MA569292) using a dilution of 1:200 (40x lens). The cells were counterstained with alpha-Tubulin Mouse mAb (AC012,dilution 1:400) (Green). DAPI was used for nuclear staining (Blue).
Product Details
MA569293
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1N7C6
Immunogen
Synthetic peptide.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.37 mg/mL
Amount
27.4 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3., with 50% glycerol, 0.05% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact; made up of network of strands to act as a molecular gasket for preventing the leakage of ions, water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Claudin-3; Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2; hRVP1; Rat ventral prostate.1 protein homolog; unnamed protein product; ventral prostate.1 protein homolog; ventral prostate.1-like protein
Gene Aliases: C7orf1; CLDN3; CPE-R2; CPETR2; HRVP1; RVP1
UniProt ID: (Human) O15551
Entrez Gene ID: (Human) 1365
response to hypoxia
epithelial cell morphogenesis
retinal pigment epithelium development
cell adhesion
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
establishment of endothelial blood-brain barrier
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
regulation of cell morphogenesis
actin cytoskeleton organization
positive regulation of cell migration
negative regulation of cell migration
cell junction assembly
cell junction maintenance
maintenance of blood-brain barrier
cell-cell junction maintenance
response to ethanol
bicellular tight junction assembly
positive regulation of wound healing
regulation of membrane permeability
response to Gram-positive bacterium
regulation of transepithelial transport
negative regulation of phosphate transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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