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Invitrogen
CRBN Recombinant Rabbit Monoclonal Antibody (1F9Y2)
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FIGURE: 1 / 8
CRBN Antibody (MA569311) in ICC/IF
Immunocytochemical analysis of CRBN in NIH/3T3 cells. Samples were incubated with CRBN recombinant monoclonal antibody (Product # MA569310) using a dilution of 1:200 (40x lens). The cells were counterstained with alpha-Tubulin Mouse mAb (AC012,dilution 1:400) (Green). DAPI was used for nuclear staining (Blue).
Product Details
MA569311
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1F9Y2
Immunogen
Recombinant protein (or fragment).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.57 mg/mL
Amount
31.4 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3., with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CRBN, a member of the Lon protease protein family, plays a role in brain development. It is a component of the DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. CRBN is thought to regulate the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. It is widely expressed and highly expressed in brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AD-006; DKFZp781K0715; MGC27358; novel lethal; Protein cereblon; Protein PiL; protein x 0001; unnamed protein product
Gene Aliases: 2610203G15Rik; 2900045O07Rik; AD-006; AF229032; AW108261; CRBN; MRT2; MRT2A; piL
UniProt ID: (Human) Q96SW2, (Mouse) Q8C7D2, (Rat) Q56AP7
Entrez Gene ID: (Human) 51185, (Mouse) 58799, (Rat) 297498
protein ubiquitination
positive regulation of Wnt signaling pathway
negative regulation of protein complex assembly
positive regulation of protein complex assembly
negative regulation of ion transmembrane transport
locomotory exploration behavior
proteasome-mediated ubiquitin-dependent protein catabolic process
limb development
proteolysis
negative regulation of protein homooligomerization
positive regulation of protein homodimerization activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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