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Invitrogen
DFNA5 Recombinant Rabbit Monoclonal Antibody (8Y3R1)
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图: 1 / 3
DFNA5 Antibody (MA569503) in ICC/IF
Immunocytochemistry analysis of DFNA5 on paraffin-embedded NCI-H522 (Doxorubicin-treated) and NCI-H522 (untreated) cell line tissue. Samples were incubated with DFNA5 recombinant monoclonal antibody (Product # MA569502) using a dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0. 01M Tris-EDTA Buffer (pH 9.0).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA569503
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
8Y3R1
抗原
Synthetic peptide.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.65 mg/mL
规格
33 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3., with 50% glycerol, 0.05% BSA
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
GSDME (Gasdermin E) is a member of the gasdermin family of pore-forming proteins that regulate programmed cell death and inflammatory signaling. Encoded by the GSDME gene, the full-length protein contains an N-terminal pore-forming domain and a C-terminal autoinhibitory domain. Under apoptotic conditions, activation of caspase-3 leads to proteolytic cleavage of GSDME, releasing the N-terminal fragment, which oligomerizes and inserts into the plasma membrane to form pores. This process can convert non-lytic apoptosis into a lytic, inflammatory form of cell death resembling pyroptosis, resulting in membrane rupture and release of intracellular contents. GSDME has been implicated in cancer biology, chemotherapy response, and tissue injury, and was originally identified in association with autosomal dominant hearing loss (historically referred to as DFNA5). Detection of cleaved GSDME is commonly used as a marker of caspase-3-mediated pore formation and inflammatory cell death.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DFNA5; Gasdermin E; Gasdermin-E; ICERE-1; Inversely correlated with estrogen receptor expression 1; Non-syndromic hearing impairment protein 5
基因别名: DFNA5; GSDME; ICERE1
Entrez Gene ID: (Human) 1687
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