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Invitrogen

IGF1R beta Recombinant Rabbit Monoclonal Antibody (PSH11-72)

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IGF1R beta Recombinant Rabbit Monoclonal Antibody (PSH11-72)

Product Details

MA569979

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

PSH11-72

Immunogen

Recombinant protein within human IGF1 Receptor aa 701-935.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.2% ProClin 950

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive control: HEK-293 cell lysate, MCF7 cell lysate, MDA-MB-231 cell lysate, A431 cell lysate, HepG2 cell lysate, A549 cell lysate, HeLa cell lysate, HUVEC cell lysate, NIH/3T3 cell lysate, C2C12 cell lysate, C6 cell lysate, Mouse brain tissue lysate, Rat brain tissue lysate.

Subcellular location: Cell membrane.

Target Information

IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of alpha- and beta-subunits, which are disulfide-linked in a beta-alpha-alpha-beta configuration in the mature receptor. The alpha-subunit is completely extracellular, while the beta-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: IGF-I receptor; insulin-like growth factor I receptor; insulin-like growth factor-I receptor precursor; line 186; protein-tyrosine kinase (EC 2.7.1.112); type-I IGF receptor; unnamed protein product

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Gene Aliases: A330103N21Rik; CD221; D930020L01; hyft; IGF-1 receptor; IGF-1R; IGFIR; IGFIRC; IGFR; Igfr1; JTK13

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UniProt ID: (Human) P08069, (Mouse) Q60751, (Rat) P24062

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Entrez Gene ID: (Human) 3480, (Mouse) 16001, (Rat) 25718

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Function(s)
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity insulin-activated receptor activity insulin-like growth factor-activated receptor activity insulin receptor binding structural molecule activity protein binding insulin-like growth factor binding ATP binding insulin-like growth factor I binding identical protein binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding G-protein alpha-subunit binding macromolecular complex binding protein transporter activity
Process(es)
protein phosphorylation immune response transmembrane receptor protein tyrosine kinase signaling pathway axonogenesis brain development positive regulation of cell proliferation insulin receptor signaling pathway epidermis development organ morphogenesis negative regulation of muscle cell apoptotic process cerebellum development establishment of cell polarity male sex determination adrenal gland development positive regulation of cell migration mammary gland development exocrine pancreas development neuron projection development positive regulation of cytokinesis cellular response to insulin stimulus positive regulation of osteoblast proliferation peptidyl-tyrosine autophosphorylation negative regulation of apoptotic process positive regulation of protein complex disassembly negative regulation of MAPK cascade positive regulation of MAPK cascade estrous cycle transcytosis response to ethanol positive regulation of mitotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of JNK cascade protein autophosphorylation insulin-like growth factor receptor signaling pathway positive regulation of developmental growth positive regulation of smooth muscle cell proliferation positive regulation of axon regeneration positive regulation of DNA metabolic process positive regulation of meiotic cell cycle positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling prostate gland epithelium morphogenesis cellular response to glucose stimulus cellular response to transforming growth factor beta stimulus positive regulation of steroid hormone biosynthetic process positive regulation of cell cycle process dendritic spine maintenance beta-amyloid clearance postsynaptic modulation of chemical synaptic transmission positive regulation of cold-induced thermogenesis response to L-glutamate negative regulation of hepatocyte apoptotic process negative regulation of cholangiocyte apoptotic process cellular response to beta-amyloid cellular response to insulin-like growth factor stimulus signal transduction protein kinase B signaling cellular response to oxygen-containing compound cardiac atrium development response to hormone hippocampus development response to nutrient levels response to insulin response to vitamin E cellular response to zinc ion starvation response to nicotine response to alkaloid cellular response to mechanical stimulus cellular response to estradiol stimulus cellular response to progesterone stimulus cellular response to testosterone stimulus cellular response to dexamethasone stimulus cellular senescence cellular response to aldosterone cellular response to angiotensin
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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