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Invitrogen
VDAC1/VDAC2/VDAC3 Recombinant Rabbit Monoclonal Antibody (PSH14-90)
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FIGURE: 1 / 2
VDAC1/VDAC2/VDAC3 Antibody (MA570038) in WB
Western blot analysis of VDAC1/VDAC2/VDAC3 in various lysates. Samples were incubated with VDAC1/VDAC2/VDAC3 monoclonal antibody (Product # MA570038) using a dilution of 1:5,000 in primary antibody dilution (K1803) at 4°C overnight followed by Goat Anti-Rabbit IgG - HRP Secondary Antibody at a dilution of 1:50,000 for 1 hour at room temperature. Lane 1: MCF7 cell lysate; Lane 2: HEK-293 cell lysate; Lane 3: Jurkat cell lysate; Lane 4: Mouse brain tissue lysate; Lane 5: Mouse heart tissue lysate; Lane 6: Rat brain tissue lysate; Lane 7: Rat... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA570038
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PSH14-90
Immunogen
Recombinant protein within human VDAC2 aa 1-294.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: MCF7 cell lysate, HEK-293 cell lysate, Jurkat cell lysate, Mouse brain tissue lysate, Mouse heart tissue lysate, Rat brain tissue lysate, Rat heart tissue lysate.
Subcellular location: Mitochondrion outer membrane, Membrane.
Target Information
VDAC1, VDAC2, and VDAC3 genes encode for voltage-dependent anion channels (VDACs) which are integral membrane proteins located in the outer mitochondrial membrane. VDAC1 is the most prominent of the three and is involved in the regulation of metabolic and energetic cross-talk between mitochondria and the rest of the cell. VDAC2 and VDAC3 share structural similarities with VDAC1 but differ in their expression patterns and regulatory functions. VDAC channels are crucial for the transport of ions and metabolites, including ATP and ADP, across the mitochondrial membrane and thus play a central role in cellular energy metabolism and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B36-VDAC; channel protein VDAC3; epididymis secretory sperm binding protein; mitochondrial outer membrane protein; mitochondrial voltage dependent anion channel 3; mVDAC3; outer mitochondrial membrane protein porin 1; outer mitochondrial membrane protein porin 2; outer mitochondrial membrane protein porin 3; plasmalemmal porin; porin 31HL; porin 31HM; rVDAC1; rVDAC3; sperm binding protein 1a; unnamed protein product; VDAC protein; VDAC-1; VDAC-2; VDAC-3; VDAC-6; VDAC2; voltage-dependent anion-selective channel protein 1; voltage-dependent anion-selective channel protein 2; voltage-dependent anion-selective channel protein 3; voltage-dependent anion-selective channel protein 5; voltage-dependent anion-selective channel protein 6
Gene Aliases: HD-VDAC3; mVDAC1; mVDAC2; mVDAC5; mVDAC6; PORIN; VDAC-1; VDAC-3; Vdac5; Vdac6
UniProt ID: (Human) P21796, (Human) P45880, (Human) Q9Y277, (Rat) Q9Z2L0, (Mouse) Q60932, (Mouse) Q60930, (Rat) P81155, (Rat) Q9R1Z0, (Mouse) Q60931
Entrez Gene ID: (Human) 7416, (Human) 7417, (Human) 7419, (Rat) 83529, (Mouse) 22333, (Mouse) 22334, (Rat) 83531, (Rat) 83532, (Mouse) 22335
voltage-gated ion channel activity
protein binding
oxysterol binding
voltage-gated anion channel activity
cholesterol binding
protein kinase binding
phosphatidylcholine binding
identical protein binding
ion channel binding
ceramide binding
phospholipid scramblase activity
anion channel activity
calcium channel activity
voltage-gated channel activity
macromolecular complex binding
behavioral fear response
chemical synaptic transmission
neuron-neuron synaptic transmission
spermatogenesis
learning
transmembrane transport
anion transmembrane transport
sperm mitochondrial sheath assembly
anion transport
binding of sperm to zona pellucida
phospholipid scrambling
phospholipid translocation
mitochondrial outer membrane permeabilization
mitochondrial transmembrane transport
negative regulation of protein polymerization
negative regulation of intrinsic apoptotic signaling pathway
mitochondrial calcium ion transport
apoptotic process
epithelial cell differentiation
calcium ion transmembrane import into mitochondrion
negative regulation of apoptotic process
negative regulation of calcium import into the mitochondrion
regulation of mitophagy
positive regulation of mitophagy
positive regulation of type 2 mitophagy
negative regulation of reactive oxygen species metabolic process
acetyl-CoA biosynthetic process from pyruvate
positive regulation of apoptotic process
pyruvate biosynthetic process
regulation of mitophagy
adenine transport
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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