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Invitrogen
N-Ras Monoclonal Antibody (25GB2770)
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FIGURE: 1 / 2
N-Ras Antibody (MA570324) in WB
Western blot analysis of N-Ras. Samples (HT-1080, HepG2, HeLa, H9C2, NIH/3T3) were incubated with N-Ras monoclonal antibody (Product # MA570323) at a dilution of 1:2,000, followed by HRP-conjugated goat anti-mouse secondary antibody (1:20,000) respectively. Image was developed using FeQ ECL Substrate Kit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA570324
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
25GB2770
Immunogen
A synthesized peptide derived from human (70-101) NRAS.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Dry ice (international)
Target Information
NRAS (GTPase NRas) is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML) and Noonan syndrome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTPase NRas; Neuroblastoma RAS; neuroblastoma RAS viral (v-ras) oncogene homolog; RAS; RASN; Transforming protein N-Ras
Gene Aliases: AV095280; HRAS1; N-ras; NRAS
UniProt ID: (Rat) Q04970
Entrez Gene ID: (Mouse) 18176, (Rat) 24605
regulation of protein phosphorylation
signal transduction
small GTPase mediated signal transduction
Ras protein signal transduction
regulation of gene expression
positive regulation of fibroblast proliferation
negative regulation of skeletal muscle tissue development
regulation of cell cycle
establishment of protein localization to Golgi
biological_process
positive regulation of cell proliferation
visual learning
actin cytoskeleton organization
regulation of synaptic transmission, GABAergic
positive regulation of Rac protein signal transduction
negative regulation of neuron apoptotic process
negative regulation of cell differentiation
regulation of long-term neuronal synaptic plasticity
striated muscle cell differentiation
epithelial tube branching involved in lung morphogenesis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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