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Invitrogen
MYH9 Monoclonal Antibody (24GB14220)
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FIGURE: 1 / 4
MYH9 Antibody (MA570793) in WB
Western blot analysis of MYH9. Samples (HT-1080, HepG2, HeLa, HAP-1, H9C2, C2C12) were incubated with MYH9 monoclonal antibody (Product # MA570793) at a dilution of 1:2,000, followed by HRP-conjugated goat anti-mouse secondary antibody (1:20,000) respectively. Image was developed using NaQECL Substrate Kit.
Product Details
MA570793
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
24GB14220
Immunogen
Recombinant protein of human (1621-1960) MYH9.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Dry ice (international)
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton that plays essential roles in various cellular processes. Structurally, the MYH9 gene spans over 106 kilobases and includes 41 exons that translate into a protein of 1,960 amino acids. This protein is a part of a hexameric complex, which includes two heavy chains, two regulatory light chains, and two essential light chains. The NMHC IIA protein interacts with actin filaments and is involved in cellular activities such as cell migration, adhesion, division, and maintenance of cell shape. Functionally, mutations in MYH9 can result in a spectrum of autosomal dominant disorders collectively known as MYH9-related diseases (MYH9-RD), which include conditions such as May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome. These disorders are primarily characterized by macrothrombocytopenia (abnormally large platelets) and may lead to other complications such as hearing loss, renal failure, and cataracts later in life. MYH9 is also crucial in hematopoiesis, where its proper function is necessary for the survival and maintenance of hematopoietic stem and progenitor cells (HSPCs). Loss of MYH9 function disrupts normal hematopoiesis, leading to severe blood cell deficiencies and bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cellular myosin heavy chain, type A; MGC104539; motor protein; MYH9; Myosin heavy chain 9; Myosin heavy chain, non-muscle IIa; myosin, heavy chain 9, non-muscle; Myosin-9; myosin9; NMHC-II A; NMMHC II-a; NMMHC IIA; NMMHC-A; non-muscle myosin heavy chain 9; Non-muscle myosin heavy chain A; Non-muscle myosin heavy chain IIa; non-muscle myosin heavy polypeptide 9; nonmuscle myosin heavy chain (NMHC); nonmuscle myosin heavy chain II-A; nonmuscle myosin IIA2; unnamed protein product
Gene Aliases: BDPLT6; DFNA17; EPSTS; FTNS; MATINS; MHA; MYH9; NMHC-II-A; NMMHC-IIA; NMMHCA
UniProt ID: (Human) P35579
Entrez Gene ID: (Human) 4627
microfilament motor activity
nucleotide binding
virus receptor activity
RNA binding
motor activity
actin binding
integrin binding
protein binding
calmodulin binding
ATP binding
protein domain specific binding
identical protein binding
protein homodimerization activity
protein anchor
ADP binding
cadherin binding
actin filament binding
meiotic spindle organization
cell morphogenesis
angiogenesis
in utero embryonic development
establishment of T cell polarity
plasma membrane repair
membrane protein ectodomain proteolysis
phagocytosis, engulfment
cytoskeleton organization
cell adhesion
integrin-mediated signaling pathway
myoblast fusion
regulation of cell shape
protein transport
actin cytoskeleton organization
actin filament-based movement
platelet formation
monocyte differentiation
actomyosin structure organization
lysosome localization
cytokinetic process
uropod organization
regulation of actin filament-based process
endodermal cell differentiation
blood vessel endothelial cell migration
regulated exocytosis
viral entry into host cell
cell motility
leukocyte migration
establishment of meiotic spindle localization
cytoplasmic actin-based contraction involved in cell motility
cortical granule exocytosis
platelet aggregation
cell-cell adhesion
negative regulation of actin filament severing
positive regulation of protein processing in phagocytic vesicle
regulation of plasma membrane repair
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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