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Invitrogen
HSD17B4 Monoclonal Antibody (25GB5635)
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图: 1 / 4
HSD17B4 Antibody (MA570904) in ICC/IF
Immunocytochemistry analysis of HSD17B4 in HeLa cells. Sample was incubated with HSD17B4 monoclonal antibody (Product # MA570903) at a dilution of 1:1,000. Top panel: wild-type (WT); Bottom panel: HSD17B4 shRNA knockdown (KD). Nuclei were stained blue with DAPI and Alexa Fluor 647. Scale bar, 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA570904
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
25GB5635
抗原
Recombinant protein of human (621-730) HSD17B4.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Dry ice (international)
靶标信息
Peroxisomal multifunctional enzyme type 2 is a protein that in humans is encoded by the HSD17B4 gene. The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; D-bifunctional protein; DBP; MFE-2; MFP-2; Multifunctional protein 2; Peroxisomal multifunctional enzyme type 2; Short chain dehydrogenase/reductase family 8C member 1
基因别名: 17-beta-HSD; 17[b]-HSD; DBP; 4; EDH17B4; HSD17B4; MFE-2; Mfp-2; MFP2; MPF-2; perMFE-2; SDR8C1
UniProt ID: (Mouse) P51660
Entrez Gene ID: (Mouse) 15488
3-hydroxyacyl-CoA dehydrogenase activity
receptor binding
oxidoreductase activity
long-chain-enoyl-CoA hydratase activity
lyase activity
isomerase activity
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
protein homodimerization activity
17-beta-hydroxysteroid dehydrogenase (NAD+) activity
very long-chain fatty acid metabolic process
osteoblast differentiation
lipid metabolic process
fatty acid metabolic process
fatty acid beta-oxidation
metabolic process
androgen metabolic process
estrogen metabolic process
very long-chain fatty-acyl-CoA metabolic process
medium-chain fatty-acyl-CoA metabolic process
oxidation-reduction process
Sertoli cell development
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
