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LRP2 Recombinant Rabbit Monoclonal Antibody (PSH04-52)

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LRP2 Recombinant Rabbit Monoclonal Antibody (PSH04-52)

产品信息

MA571383

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:2,000
-

免疫组化（石蜡） (IHC (P))

1:1,000
-

免疫细胞化学 (ICC/IF)

1:100
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

PSH04-52

抗原

Recombinant protein within human Lrp2 aa 2,500-3,200 / 4,655.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein A

保存液

PBS, pH 7.4, with 40% glycerol, 0.1% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Positive Control: Human kidney tissue lysate, mouse kidney tissue lysate, rat kidney tissue lysate, human kidney tissue, mouse kidney tissue, rat kidney tissue.

Tissue Specificity: Tissue enhanced (kidney, parathyroid gland, retina)

Subcellular Location: Apical cell membrane, Endosome lumen, Membrane, coated pit, Cell projection, dendrite, axon.

Sequence Similarities: 75% Mouse/Rat

Predicted band size: 522 kDa.

靶标信息

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: calcium sensor protein; Glycoprotein 330; gp330; Heymann nephritis antigen homolog; low density lipoprotein-related protein 2; Low-density lipoprotein receptor-related protein 2; LRP-2; Megalin; transmembrane receptor; unnamed protein product

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基因别名: AI315343; AW536255; b2b1625.2Clo; D230004K18Rik; DBS; GP330; LRP-2; LRP2; Megalin

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UniProt ID: (Human) P98164, (Rat) P98158, (Mouse) A2ARV4

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Entrez Gene ID: (Human) 4036, (Rat) 29216, (Mouse) 14725

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功能
low-density lipoprotein receptor activity calcium ion binding protein binding SH3 domain binding insulin-like growth factor I binding cargo receptor activity hormone binding metal ion binding chaperone binding protein transporter activity receptor activity PDZ domain binding hemoglobin binding protein complex binding lipoprotein transporter activity low-density lipoprotein particle receptor binding Wnt-protein binding Wnt-activated receptor activity transmembrane signal receptor
参与通路
retinoid metabolic process kidney development neural tube closure secondary heart field specification outflow tract septum morphogenesis outflow tract morphogenesis ventricular compact myocardium morphogenesis ventricular septum development lipid metabolic process endocytosis receptor-mediated endocytosis nervous system development heart development sensory perception of sound cell proliferation male gonad development gene expression protein transport cobalamin transport metal ion transport negative regulation of BMP signaling pathway forebrain development diol metabolic process aorta development vitamin D metabolic process negative regulation of apoptotic process protein kinase B signaling response to leptin transcytosis positive regulation of neurogenesis vitamin transport vagina development coronary vasculature development coronary artery morphogenesis pulmonary artery morphogenesis positive regulation of oligodendrocyte progenitor proliferation cellular response to growth factor stimulus beta-amyloid clearance neuron projection arborization transport across blood-brain barrier folic acid import into cell cranial skeletal system development positive regulation of lysosomal protein catabolic process vitamin metabolic process aging response to X-ray negative regulation of endopeptidase activity endosomal transport hemoglobin import organ regeneration response to retinoic acid response to vitamin D response to drug lipoprotein transport hormone secretion Wnt signaling pathway involved in dorsal/ventral axis specification canonical Wnt signaling pathway
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