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Invitrogen
CTGF Recombinant Rabbit Monoclonal Antibody (PSH15-64)
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图: 1 / 23
CTGF Antibody (MA571389) in ICC/IF
Immunofluorescence analysis of CTGF using HepG2 (positive) and MCF7 (low expression). The cells were fixed in 4% paraformaldehyde for 20 minutes at room temperature, permeabilized with 0.1% Triton X-100 in PBS for 5 minutes at room temperature, then blocked with 1% BSA in 10% negative goat serum for 1 hour at room temperature. The cells were co-labeled with CTGF Recombinant Rabbit Monoclonal Antibody (PSH15-64) (Product # MA571389) (green) at 1:2,000 and beta tubulin (red) at 1:100 dilution in 1% BSA in PBST overnight at 4 degrees Celsius ... View More
产品信息
MA571389
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH15-64
抗原
Recombinant protein within human CTGF aa 1-349.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.2% ProClin 950
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive Control: PANC-1 cell lysate, HepG2 cell lysate, HFF-1 cell lysate, Mouse heart tissue lysate, Rat heart tissue lysate, human heart tissue, human kidney tissue, mouse heart tissue, mouse kidney tissue, rat heart tissue, rat kidney tissue, HepG2.
Tissue Specificity: Low tissue specificity
Subcellular Location: Secreted, extracellular space, extracellular matrix.
Sequence Similarities: 90% Mouse/Rat
Predicted band size: 38 kDa.
靶标信息
Connective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. CTGF plays important roles in the proliferation and differentiation of chondrocytes, induces angiogenesis, and promotes cell adhesion in fibroblasts, endothelial, and epithelial cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2-Nov; CCN family member 2; Cellular communication network factor 2; Connective tissue growth factor; Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24); Connective tissue growth-related protein; CTGF; fibroblast inducible secreated protein; fibroblast inducible secreted protein; H-CTGF; hypertrophic chondrocyte-specific gene product 24; Hypertrophic chondrocyte-specific protein 24; IBP-8; IGF-binding protein 8; Insulin-like growth factor-binding protein 8; MGC102839; Protein FISP-12; unnamed protein product
基因别名: betaIG-M2; CCN2; CTGF; CTGRP; Fisp-12; Fisp12; HCS24; IBP-8; IGFBP8; KMD; NOV2; SEMDLSL
UniProt ID: (Human) P29279, (Mouse) P29268, (Rat) Q9R1E9
Entrez Gene ID: (Human) 1490, (Mouse) 14219, (Rat) 64032
cartilage condensation
ossification
angiogenesis
osteoblast differentiation
tissue homeostasis
chondrocyte differentiation
cell adhesion
cell-matrix adhesion
signal transduction
integrin-mediated signaling pathway
fibroblast growth factor receptor signaling pathway
epidermis development
response to wounding
negative regulation of gene expression
cell migration
lung development
regulation of chondrocyte differentiation
chondrocyte proliferation
positive regulation of cell differentiation
positive regulation of JNK cascade
regulation of developmental process
positive regulation of stress fiber assembly
connective tissue development
positive regulation of ERK1 and ERK2 cascade
DNA biosynthetic process
reactive oxygen species metabolic process
regulation of cell growth
positive regulation of protein phosphorylation
cell-cell signaling
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of cell death
cell differentiation
positive regulation of collagen biosynthetic process
intracellular signal transduction
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cell activation
cytosolic calcium ion transport
positive regulation of cardiac muscle contraction
negative regulation of cell death
extracellular matrix constituent secretion
positive regulation of G0 to G1 transition
response to glucose
organ senescence
response to organic cyclic compound
response to estradiol
response to anoxia
response to amino acid
response to peptide hormone
response to mineralocorticoid
response to fatty acid
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