Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex.
AuthorsNakano H, Yamazaki T, Miyatake S, Nozaki N, Kikuchi A, Saito T
JournalJ Biol Chem
PubMed ID8626450
'T cell antigen receptor (TCR)-CD3 complex is composed of six different subunits: TCR alpha and TCR beta and CD3 gamma, CD3 delta, CD3 epsilon, and CD3 eta. Antigen recognition signals are transduced from TCR to the cytoplasm through the cytoplasmic domain of the CD3 chains. To understand the downstream signal ... More
In situ analysis of the evolution of the primary immune response in murine Chlamydia trachomatis genital tract infection.
AuthorsMorrison SG, Morrison RP
JournalInfect Immun
PubMed ID10768984
'Adaptive immune responses contribute to the resolution of Chlamydia trachomatis genital tract infection and protect against reinfection, but our understanding of the mechanisms of those protective responses is incomplete. In this study, we analyzed by in situ immunohistochemistry the progression of the inflammatory and cytokine responses in the genital tracts ... More
Identification of a monoclonal antibody specific for a murine T3 polypeptide.
AuthorsLeo O, Foo M, Sachs DH, Samelson LE, Bluestone JA
JournalProc Natl Acad Sci U S A
PubMed ID2950524
A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a 25-kDa protein component (T3-epsilon) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can both activate and inhibit ... More
Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes.
AuthorsHavran WL, Poenie M, Kimura J, Tsien R, Weiss A, Allison JP
JournalNature
PubMed ID2959867
Mature T cells arise from progenitor cells by a complex and poorly understood process of differentiation in the thymus. Thymocytes can be divided into four major compartments on the basis of surface expression of the murine equivalents of CD8 (Lyt-2) and CD4 (L3T4) (refs 1,2). Functionally mature thymocytes express only ... More
Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2-secreting tumors.
There is considerable evidence to demonstrate that immune function is abnormal in tumor-bearing mice, perhaps accounting, at least in part, for progressive tumor growth. In an attempt to generate an antitumor response, we used retroviral vectors to express IL-2 cDNA in CMS5, a murine fibrosarcoma. Mice inoculated with unmodified tumor ... More