Phenotypic and genotypic heterogeneity in infant acute leukemia. II. Acute nonlymphoblastic leukemia.
AuthorsKöller U, Haas OA, Ludwig WD, Bartram CR, Harbott J, Panzer-Grümayer R, Hansen-Hagge T, Ritter J, Creutzig U, Knapp W
JournalLeukemia
PubMed ID2779287
'We have studied the immunophenotypic and genotypic characteristic of acute nonlymphoblastic leukemias (ANLL) in infants aged less than one year. Sixty-four percent of cases (16/25) showed a myeloid or myelomonocytic differentiation pattern and 10 of these were classified as FAB M5 (7 M5a, 3 M5b). Only seven of the latter ... More
Prognostic value of immunological markers in acute myeloblastic leukemia.
AuthorsSan Miguel JF, Ojeda E, Gonzalez M, Orfao A, Cañizo MC, Sanchez J, Lopez-Borrasca A
JournalLeukemia
PubMed ID2911203
In order to investigate the prognostic value of immunologic markers together with the most relevant clinical and hematological disease characteristics in acute myeloblastic leukemia (AML), the reactivity of blast cells from 102 patients with AML was analyzed with a panel of twenty monoclonal antibodies. The univariate analysis showed that five ... More
Phenotypic and genotypic heterogeneity in infant acute leukemia. I. Acute lymphoblastic leukemia.
We have studied the immunophenotypic and genotypic features in 35 infants aged less than 1 year with acute lymphoblastic leukemia (ALL) or acute undifferentiated leukemia (AUL). A CD10 (common ALL antigen)-negative, CD19-positive pre-pre-B ALL phenotype was observed in 24 infants. Seventeen of them had blast cells coexpressing myeloid-associated markers such ... More