Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody.
AuthorsNicolls MR, Aversa GG, Pearce NW, Spinelli A, Berger MF, Gurley KE, Hall BM
JournalTransplantation
PubMed ID8456460
'Monoclonal antibodies to CD3 have been shown to activate T cells in vivo and in vitro but have also been shown to render T cells anergic in vitro. In this study G4.18, a mouse IgG3 mAb, was produced that appeared to recognize CD3 by its binding to all peripheral T ... More
Characterization of a CD3-like rat T cell surface antigen recognized by a monoclonal antibody.
AuthorsTanaka T, Masuko T, Yagita H, Tamura T, Hashimoto Y
JournalJ Immunol
PubMed ID2467940
A mouse mAb, which recognized a rat T cell surface Ag responsible for the T cell activation, was produced by a regular hybridoma method using F344 rat T cells stimulated with PMA and a calcium ionophore, as the Ag. The mAb termed 1F4 (kappa-IgM) was reactive with rat T cells ... More