Imaging beta-galactosidase activity in human tumor xenografts and transgenic mice using a chemiluminescent substrate.
AuthorsLiu L, Mason RP
JournalPLoS One
PubMed ID20700459
Detection of enzyme activity or transgene expression offers potential insight into developmental biology, disease progression, and potentially personalized medicine. Historically, the lacZ gene encoding the enzyme beta-galactosidase has been the most common reporter gene and many chromogenic and fluorogenic substrates are well established, but limited to histology or in vitro ... More