Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury.
AuthorsBareyre FM, Kerschensteiner M, Misgeld T, Sanes JR
JournalNat Med
PubMed ID16286922
'The rodent corticospinal tract (CST) has been used extensively to investigate regeneration and remodeling of central axons after injury. CST axons are currently visualized after injection of tracer dye, which is invasive, incomplete and prone to variation, and often does not show functionally crucial but numerically minor tract components. Here, ... More
A new method for imaging and 3D reconstruction of mammalian cochlea by fluorescent confocal microscopy.
AuthorsHardie NA, MacDonald G, Rubel EW
JournalBrain Res
PubMed ID15053969
'Traditional methods for anatomical and morphometric studies of cochlear tissues have relied upon either microdissection of the organ of Corti or the generation of serial sections of the cochlea. Such methods are time-consuming, disruptive to three-dimensional relationships and often restrict sampling to very limited numbers of cells. We have found ... More
Characterization of nestin expression in the spinal cord of GFP transgenic mice after peripheral nerve injury.
AuthorsMatsumura S, Takagi K, Okuda-Ashitaka E, Lu J, Naritsuka H, Yamaguchi M, Ito S,
JournalNeuroscience
PubMed ID20673789
'Many studies have shown that activation and increase in the number of astrocytes and microglia in the spinal cord participate in the initiation and maintenance of neuropathic pain, but little attention has been paid to the responses of neural progenitor cells to peripheral nerve injury. Nestin, a class VI intermediate ... More
Synfire chains and cortical songs: temporal modules of cortical activity.
AuthorsIkegaya Y, Aaron G, Cossart R, Aronov D, Lampl I, Ferster D, Yuste R
JournalScience
PubMed ID15105494
How can neural activity propagate through cortical networks built with weak, stochastic synapses? We find precise repetitions of spontaneous patterns of synaptic inputs in neocortical neurons in vivo and in vitro. These patterns repeat after minutes, maintaining millisecond accuracy. Calcium imaging of slices reveals reactivation of sequences of cells during ... More
RNAi reveals doublecortin is required for radial migration in rat neocortex.
AuthorsBai J, Ramos RL, Ackman JB, Thomas AM, Lee RV, LoTurco JJ
JournalNat Neurosci
PubMed ID14625554
Mutations in the doublecortin gene (DCX) in humans cause malformation of the cerebral neocortex. Paradoxically, genetic deletion of Dcx in mice does not cause neocortical malformation. We used electroporation of plasmids encoding short hairpin RNA to create interference (RNAi) of DCX protein in utero, and we show that DCX is ... More
AuthorsSekirnjak C, Vissel B, Bollinger J, Faulstich M, du Lac S
JournalJ Neurosci
PubMed ID12867525
The cerebellum controls motor learning via Purkinje cell synapses onto discrete populations of neurons in the deep cerebellar nuclei and brainstem vestibular nuclei. In the circuitry that subserves the vestibulo-ocular reflex, the postsynaptic targets of Purkinje cells, termed flocculus target neurons (FTNs), are thought to be a critical site of ... More
Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse.
AuthorsMiterko LN, White JJ, Lin T, Brown AM, O'Donovan KJ, Sillitoe RV
JournalNeural Dev
PubMed ID30867000
'Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8'
Age- and a-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri.
AuthorsMatsui H, Kenmochi N, Namikawa K
JournalCell Rep
PubMed ID30759385
'Parkinson''s disease (PD) is a neurodegenerative disease characterized by a-synuclein-positive inclusion bodies and loss of neurons, including dopaminergic neurons. Difficulty in replicating PD phenotypes using animal models partly limits the understanding of PD and the therapy required. Although PD is strongly associated with aging, most experimental animals may not exhibit ... More
Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.
AuthorsSong M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M, Tam TW, Jamieson K, Lu SY, Ming GL, Li Y, Yao J, Weiss LA, Dixon JR, Judge LM, Conklin BR, Song H, Gan L, Shen Y
JournalNat Genet
PubMed ID31367015
'Mutations in gene regulatory elements have been associated with a wide range of complex neuropsychiatric disorders. However, due to their cell-type specificity and difficulties in characterizing their regulatory targets, the ability to identify causal genetic variants has remained limited. To address these constraints, we perform an integrative analysis of chromatin ... More
In utero infection of Zika virus leads to abnormal central nervous system development in mice.
AuthorsZhang W, Tan YW, Yam WK, Tu H, Qiu L, Tan EK, Chu JJH, Zeng L
JournalSci Rep
PubMed ID31086212
'The World Health Organization has declared ZIKA virus (ZIKV) a global public health emergency, prompted by the association of ZIKV infections with severe brain abnormalities in the human fetus. ZIKV preferentially targets human neuronal precursor cells (NPCs) in both monolayer and cortical brain organoid culture systems and stunts their growth. ... More
Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations.
AuthorsChen P, Lou S, Huang ZH, Wang Z, Shan QH, Wang Y, Yang Y, Li X, Gong H, Jin Y, Zhang Z, Zhou JN
JournalNeuron
PubMed ID32101698
'In response to stressors, individuals adopt different behavioral styles, which are essential for survival and form the basis of differential susceptibility to stress-related disorders. Corticotropin-releasing factor (CRF) and the medial prefrontal cortex (mPFC) have predominantly been studied in behavioral response to stress, while the role of mPFC CRF neurons is poorly ... More
Strict Independence of Parallel and Poly-synaptic Axon-Target Matching during Visual Reflex Circuit Assembly.
Authors
JournalCell Rep
PubMed ID29241535
Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration.
Authors
JournalNat Neurosci
PubMed ID27526204
Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration.
Authors
JournalElife
PubMed ID34473622
De novo inter-regional coactivations of preconfigured local ensembles support memory.
Authors
JournalNat Commun
PubMed ID35277492
Basolateral Amygdala Drives a GPCR-Mediated Striatal Memory Necessary for Predictive Learning to Influence Choice.
Authors
JournalNeuron
PubMed ID32240599
A cerebello-olivary signal for negative prediction error is sufficient to cause extinction of associative motor learning.
Authors
JournalNat Neurosci
PubMed ID33169031
TACAN Is an Ion Channel Involved in Sensing Mechanical Pain.
Authors
JournalCell
PubMed ID32084332
Microbiota modulate sympathetic neurons via a gut-brain circuit.
Authors
JournalNature
PubMed ID32641826
Biohybrid Carbon Nanotube/Agarose Fibers for Neural Tissue Engineering.
Authors
JournalAdv Funct Mater
PubMed ID21887125
A Basal Ganglia Circuit Sufficient to Guide Birdsong Learning.