Molecular characterization of a metastatic neuroendocrine cell cancer arising in the prostates of transgenic mice.
AuthorsHu Y, Ippolito JE, Garabedian EM, Humphrey PA, Gordon JI,
JournalJ Biol Chem
PubMed ID12228243
The features and functions of prostatic neuroendocrine (NE) cells remain ill-defined. Neuroendocrine differentiation (NED) in adenocarcinoma of the human prostate (CaP) is associated with more aggressive disease, but the underlying mediators are poorly understood. We examined these issues in transgenic mice that utilize regulatory elements from the cryptdin-2 gene (Defcr2) ... More