Inhibition of the human thioredoxin system. A molecular mechanism of mercury toxicity.
AuthorsCarvalho CM, Chew EH, Hashemy SI, Lu J, Holmgren A,
JournalJ Biol Chem
PubMed ID18321861
Mercury toxicity mediated by different forms of mercury is a major health problem; however, the molecular mechanisms underlying toxicity remain elusive. We analyzed the effects of mercuric chloride (HgCl(2)) and monomethylmercury (MeHg) on the proteins of the mammalian thioredoxin system, thioredoxin reductase (TrxR) and thioredoxin (Trx), and of the glutaredoxin ... More
Heat shock protein-70 expressed on the surface of cancer cells binds parathyroid hormone-related protein in vitro.
AuthorsGrzesiak JJ, Smith KC, Chalberg C, Truong C, Burton DW, Deftos LJ, Bouvet M,
JournalEndocrinology
PubMed ID15878959
Recent studies have shown that the functions of PTH-related protein (PTHrP) and its derived peptides cannot be attributed solely to PTH/PTHrP receptor binding. The present study focused on the identification of other proteins that might bind PTHrP at the cell surface. Using affinity chromatography, we applied extracts of cell-surface biotinylated ... More