Allergic airways disease develops after an increase in allergen capture and processing in the airway mucosa.
Authorsvon Garnier C, Wikstrom ME, Zosky G, Turner DJ, Sly PD, Smith M, Thomas JA, Judd SR, Strickland DH, Holt PG, Stumbles PA,
JournalJ Immunol
PubMed ID17947647
'Airway mucosal dendritic cells (AMDC) and other airway APCs continuously sample inhaled Ags and regulate the nature of any resulting T cell-mediated immune response. Although immunity develops to harmful pathogens, tolerance arises to nonpathogenic Ags in healthy individuals. This homeostasis is thought to be disrupted in allergic respiratory disorders such ... More
Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation.
AuthorsBurgdorf S, Kautz A, Böhnert V, Knolle PA, Kurts C
JournalScience
PubMed ID17463291
The mechanisms that allow antigen-presenting cells (APCs) to selectively present extracellular antigen to CD8+ effector T cells (cross-presentation) or to CD4+ T helper cells are not fully resolved. We demonstrated that APCs use distinct endocytosis mechanisms to simultaneously introduce soluble antigen into separate intracellular compartments, which were dedicated to presentation ... More
Differential ability of surface and endosomal TLRs to induce CD8 T cell responses in vivo.
AuthorsMandraju R, Murray S, Forman J, Pasare C,
Journal
PubMed ID24688022
TLR activation on dendritic cells (DCs) induces DC maturation and secretion of proinflammatory cytokines, both of which are important for activation and differentiation of CD4 T cells. The importance of TLR activation on DCs for CD8 T cell responses is less clear. In this study, we tested the ability of ... More
Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus.
AuthorsLoving CL, Brockmeier SL, Sacco RE
JournalImmunology
PubMed ID17116172
Dendritic cells (DCs) play a role in anti-viral immunity by providing early innate protection against viral replication and by presenting antigen to T cells for initiation of the adaptive immune response. Studies show the adaptive response to porcine reproductive and respiratory syndrome virus (PRRSV) is ineffective for complete viral elimination. ... More
Coordinated changes in glycosylation regulate the germinal center through CD22.
Authors
JournalCell Rep
PubMed ID35294874
An Ectoderm-Derived Myeloid-like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis.
AuthorsLin X, Zhou Q, Zhao C, Lin G, Xu J, Wen Z
JournalDev Cell
PubMed ID31006648
'Tissue-resident macrophages (TRMs) are highly heterogeneous and engage in a wide range of diverse functions. Yet, the heterogeneities of their origins and functions remain incompletely defined. Here, we report the identification and characterization of an ectoderm-derived myeloid-like cell, which we refer to as metaphocyte. We show that metaphocytes are highly ... More
SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance.
Authors
JournalCell Rep
PubMed ID34320354
Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis.
Authors
JournalProc Natl Acad Sci U S A
PubMed ID32541026
Endoderm-Derived Myeloid-like Metaphocytes in Zebrafish Gill Mediate Soluble Antigen-Induced Immunity.
Authors
JournalCell Rep
PubMed ID33027664
Downregulation of low-density lipoprotein receptor mRNA in lymphatic endothelial cells impairs lymphatic function through changes in intracellular lipids.
Authors
JournalTheranostics
PubMed ID35154499
IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells.
Authors
JournalCell Rep
PubMed ID35172161
Antigen-loaded monocyte administration induces potent therapeutic antitumor T cell responses.
Authors
JournalJ Clin Invest
PubMed ID31661470
A purine metabolic checkpoint that prevents autoimmunity and autoinflammation.
Authors
JournalCell Metab
PubMed ID34986329
A sequential 3D bioprinting and orthogonal bioconjugation approach for precision tissue engineering.
Authors
JournalBiomaterials
PubMed ID32805500
The droplet size of emulsion adjuvants has significant impact on their potency, due to differences in immune cell-recruitment and -activation.
AuthorsShah RR, Taccone M, Monaci E, Brito LA, Bonci A, O'Hagan DT, Amiji MM, Seubert A
JournalSci Rep
PubMed ID31395915
Self-emulsification is routinely used for oral delivery of lipophilic drugs in vivo, with the emulsion forming in vivo. We modified this technique to prepare novel oil-in-water emulsions of varying droplet size and composition on bench to enable adjuvanted vaccine delivery. We used these formulations to show that smaller droplets (20?nm) ... More
Dlg1 Maintains Dendritic Cell Function by Securing Voltage-Gated K
AuthorsDong X, Wei L, Guo X, Yang Z, Wu C, Li P, Lu L, Qi H, Shi Y, Hu X, Wu L, Chen L, Liu W
JournalJ Immunol
PubMed ID31028120
Dendritic cells (DCs) play key roles in Ab responses by presenting Ags to lymphocytes and by producing proinflammatory cytokines. In this study, we reported that DC-specific knockout of discs large homologue 1 (Dlg1) resulted in a significantly reduced capacity to mediate Ab responses to both thymus-independent and thymus-dependent Ags in ... More
Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections.
AuthorsCai R, Pan C, Ghasemigharagoz A, Todorov MI, Förstera B, Zhao S, Bhatia HS, Parra-Damas A, Mrowka L, Theodorou D, Rempfler M, Xavier ALR, Kress BT, Benakis C, Steinke H, Liebscher S, Bechmann I, Liesz A, Menze B, Kerschensteiner M, Nedergaard M, Ertürk A
JournalNat Neurosci
PubMed ID30598527
Analysis of entire transparent rodent bodies after clearing could provide holistic biological information in health and disease, but reliable imaging and quantification of fluorescent protein signals deep inside the tissues has remained a challenge. Here, we developed vDISCO, a pressure-driven, nanobody-based whole-body immunolabeling technology to enhance the signal of fluorescent ... More
Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells.
Despite a broad cell-type tropism, cytomegalovirus (CMV) is an evidentially pulmonary pathogen. Predilection for the lungs is of medical relevance in immunocompromised recipients of hematopoietic cell transplantation, in whom interstitial CMV pneumonia is a frequent and, if left untreated, fatal clinical manifestation of human CMV infection. A conceivable contribution of ... More