Mutations in the mitochondrial genome are associated with a wide range of neurological symptoms, but many aspects of the basic neuronal pathology are not understood. One candidate mechanism, given the well-established role of mitochondria in calcium buffering, is a deficit in neuronal calcium homoeostasis. We therefore examined calcium responses in ... More
Second harmonic and sum frequency generation imaging of fibrous astroglial filaments in ex vivo spinal tissues.
AuthorsFu Y, Wang H, Shi R, Cheng JX
JournalBiophys J
PubMed ID17293404
Sum frequency generation (SFG) and second harmonic generation (SHG) were observed from helical fibrils in spinal cord white matter isolated from guinea pigs. By combining SFG with coherent anti-Stokes Raman scattering microscopy, which allows visualization of myelinated axons, these fibers were found to be distributed near the surface of the ... More
PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development.