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Invitrogen
Phospho-STAT3 (Tyr705) Polyclonal Antibody
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产品信息
OPA1-03008
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphorylated peptide derived from the region of human STAT3 that contains tyrosine 705.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
OPA1-03008 detects phosphorylated signal transducer and activator of transcription 3 (STAT3) from human, mouse, and rat tissues and cells. This antibody is specific for phosphorylated STAT3 and does not cross-react with unphosphorylated STAT3. OPA1-03007 does not detect any other STATs or related proteins.
OPA1-03008 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~92 kDa protein representing phosphorylated STAT3 from HeLa and 3T3L1 cell lysate. Previous lots of OPA1-03008 were used in flow cytometry.
The OPA1-03008 immunizing peptide is a synthetic phosphorylated peptide derived from the region of human STAT3 that contains tyrosine 705.
Store at -20c. For shipment or short term storage (up to one week), 2-8c is sufficient.
靶标信息
STAT3 belongs to the family of STAT (signal transducers and activators of transcription) proteins which are phosphorylated by receptor associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors. Coactivators such as CREB-binding protein are required for the transcriptional activation by STAT3. STAT3 can also be activated by Interferon-alpha, Interferon-gamma, EGF, PDGF and IL6. Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for STAT3 dimer formation, nuclear translocation, and DNA binding activity. In humans, the STAT3 gene is located on the q arm of chromosome 17. STAT3 has been shown to be activated by IFN-alpha but not IFN-beta. The transcription factors associated with STAT3 are c-Jun and cyclic AMP-responsive enhancer binding protein (CREB). STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3 while the PIAS3 protein is a specific inhibitor of STAT3. Three alternatively spliced transcript variants encoding distinct isoforms of STAT3 have been described. Deletion of the STAT3 gene in knock-out mice was lethal at the early embryonic stage.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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