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Invitrogen
JAK2 Polyclonal Antibody
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产品信息
OPA1-03052A
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide derived from the C-terminus of human JAK2.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
OPA1-03052A detects JAK2 in human and mouse samples. This antibody is expected to react with rat samples based on 100% sequence homology.
OPA1-03052A has been successfully used in Western blotting. By Western blot, this antibody detects an ~130 kDa protein representing JAK2. This antibody is useful in measuring total JAK2 protein levels.
The OPA1-03052A immunogen is a synthetic peptide derived from the C-terminus region of human JAK2. This sequence is conserved in rat and mouse.
Positive Control: Human epidermoid carcinoma (A431) cells, NIH3T3 cells.
靶标信息
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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