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Invitrogen
Phospho-JAK2 (Tyr1007, Tyr1008) Polyclonal Antibody
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产品信息
OPA1-03053A
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide derived from a region of mouse JAK2 that contains tyrosines 1007 and 1008.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
OPA1-03053A detects phospho-JAK2 (pTyr 1007/1008) in mouse samples. This antibody may cross-react with phospho-JAK1 (pTyr 1022/1023) due to homology (73%).
OPA1-03053A has been successfully used in Western blotting. By Western blot, this antibody detects an ~130 kDa protein representing JAK2 phosphorylated at tyrosine 1007 and 1008.
The OPA1-03053A immunogen is a synthetic peptide derived from mouse JAK2 that is phosphorylated at tyrosines 1007 and 1008.. This sequence is conserved in rat.
靶标信息
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
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