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Invitrogen
Phospho-p38 MAPK alpha (Thr180, Tyr182) Polyclonal Antibody
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产品信息
OPA1-03080
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from human p38 that contains phosphorylated threonine 180 and tyrosine 182.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
OPA1-03080 detects phospho-p38 alpha, beta, and gamma from human and rat tissues and cells. This antibody is expected to react with mouse, canine, monkey, and carp phospho-p38 based on sequence homology.
OPA1-03080 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~38 kDa protein representing phospho-p38 from platelet-derived growth factor (PDGF) treated NIH-3T3 cell extract.
OPA1-03080 immunizing phosphopeptide was derived from human p38 that contains phosphorylated threonine 180 and tyrosine 182.
靶标信息
MAPK14 (p38 alpha) is a member of the stress-activated protein kinase class of MAPKs. The p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in the nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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