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Invitrogen
Phospho-SRC (Tyr529) Polyclonal Antibody
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Product Details
OPA1-03092
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from human Src that contains phosphorylated tyrosine 529.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
OPA1-03092 detects p-Src from human, mouse, rat and chicken tissues and cells.
OPA1-03092 has been successfully used in Western blot. Previous lots of this antibody have been used in immunohistochemistry procedures. By Western blot, this antibody detects an ~60 kDa protein representing p-Src from platelet-derived growth factor (PDGF) treated NIH-3T3 cell extract.
OPA1-03092 immunizing phosphopeptide was derived from human Src that contains phosphorylated tyrosine 529.
Target Information
SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth. SRC is involved in the regulation of growth and differentiation of eukaryotic cells. SRC associates with the cytoplasmic region of various cell surface receptors to facilitate signal transduction, and is also involved in cytoskeletal organization, cell cycle regulation, and apoptosis. In humans, the gene encoding SRC is present on chromosome 20. Activity of SRC is regulated by two tyrosine residues (Tyr 416 and Tyr527), and phosphorylation of these two sites have opposing effects. Phosphorylation of Tyr416 in the activation loop of the kinase domain upregulates enzyme activity while the phosphorylation of Tyr527 decreases enzyme activity. Mutations in the SRC gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been found thus far.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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