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Invitrogen
Phospho-SRC (Tyr529) Polyclonal Antibody
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产品信息
OPA1-03092
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from human Src that contains phosphorylated tyrosine 529.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
OPA1-03092 detects p-Src from human, mouse, rat and chicken tissues and cells.
OPA1-03092 has been successfully used in Western blot. Previous lots of this antibody have been used in immunohistochemistry procedures. By Western blot, this antibody detects an ~60 kDa protein representing p-Src from platelet-derived growth factor (PDGF) treated NIH-3T3 cell extract.
OPA1-03092 immunizing phosphopeptide was derived from human Src that contains phosphorylated tyrosine 529.
靶标信息
SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth. SRC is involved in the regulation of growth and differentiation of eukaryotic cells. SRC associates with the cytoplasmic region of various cell surface receptors to facilitate signal transduction, and is also involved in cytoskeletal organization, cell cycle regulation, and apoptosis. In humans, the gene encoding SRC is present on chromosome 20. Activity of SRC is regulated by two tyrosine residues (Tyr 416 and Tyr527), and phosphorylation of these two sites have opposing effects. Phosphorylation of Tyr416 in the activation loop of the kinase domain upregulates enzyme activity while the phosphorylation of Tyr527 decreases enzyme activity. Mutations in the SRC gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been found thus far.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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