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Invitrogen
Phospho-EGFR (Tyr1173) Polyclonal Antibody
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产品信息
OPA1-03173
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide derived from a region of human EGFR that contains tyrosine 1173.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
OPA1-03173 detects human phospho-EGFR (pTyr1173) from human samples. Mouse, rat and chicken are expected to cross-react due to sequence homology.
OPA1-03173 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~185 kDa protein representing phospho-EGFR (pTyr1173).
OPA1-03173 immunizing phosphopeptide was derived from a region of human EGFR that contains tyrosine 1173.
靶标信息
EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. EGFR is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
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