JournalJournal of immunology (Baltimore, Md. : 1950)
PubMed ID17548610
Extensive diversity of Ig-superfamily proteins in the immune system of insects.
AuthorsWatson FL, Püttmann-Holgado R, Thomas F, Lamar DL, Hughes M, Kondo M, Rebel VI, Schmucker D
JournalScience
PubMed ID16109846
'The extensive somatic diversification of immune receptors is a hallmark of higher vertebrates. However, whether molecular diversity contributes to immune protection in invertebrates is unknown. We present evidence that Drosophila immune-competent cells have the potential to express more than 18,000 isoforms of the immunoglobulin (Ig)-superfamily receptor Down syndrome cell adhesion ... More
Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1.
AuthorsGómez MI, Lee A, Reddy B, Muir A, Soong G, Pitt A, Cheung A, Prince A
JournalNat Med
PubMed ID15247912
Staphylococcus aureus is a major human pathogen that is associated with diverse types of local and systemic infection characterized by inflammation dominated by polymorphonuclear leukocytes. Staphylococci frequently cause pneumonia, and these clinical isolates often have increased expression of protein A, suggesting that this protein may have a role in virulence. ... More
CD4 promotes breadth in the TCR repertoire.
AuthorsWang Q, Malherbe L, Zhang D, Zingler K, Glaichenhaus N, Killeen N
JournalJ Immunol
PubMed ID11591754
A diverse population of MHC class II-restricted CD4 lineage T cells develops in mice that lack expression of the CD4 molecule. In this study, we show that the TCR repertoire selected in the absence of CD4 is distinct, but still overlapping in its properties with that selected in the presence ... More
Non-natural cell surface receptors: synthetic peptides capped with N-cholesterylglycine efficiently deliver proteins into Mammalian cells.
AuthorsMartin SE, Peterson BR
JournalBioconjug Chem
PubMed ID12526694
Protein toxins such as shiga toxin and cholera toxin penetrate into cells by binding small molecule-based cell surface receptors localized to cholesterol and sphingolipid-rich lipid raft subdomains of cellular plasma membranes. Molecular recognition between these toxins and their receptors triggers endocytic protein uptake through endogenous membrane trafficking pathways. We report ... More