Estrogen facilitates neurite extension via apolipoprotein E in cultured adult mouse cortical neurons.
AuthorsNathan BP, Barsukova AG, Shen F, McAsey M, Struble RG,
JournalEndocrinology
PubMed ID15033916
Literature review suggests a close relationship between estrogen and apolipoprotein E (ApoE) in the central nervous system. Epidemiology studies show that estrogen replacement therapy (ERT) decreases the morbidity from several chronic neurological diseases. Alleles of ApoE modify the risk for and progression of the same diseases. ApoE levels in the ... More