Antibody-guided enzyme therapy of cancer producing cyanide results in necrosis of targeted cells.
AuthorsKousparou CA, Epenetos AA, Deonarain MP
JournalInt J Cancer
PubMed ID11948505
A number of enzyme/prodrug activation approaches for the treatment of cancer have been reported to date with varying success. We describe progress in the development of a system based on a beta-glucosidase enzyme in combination with a naturally occurring "prodrug," the sugar linamarin, which releases the cytotoxin cyanide. A recombinant ... More