Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases.
AuthorsDeng X, Ruvolo P, Carr B, May WS,
JournalProc Natl Acad Sci U S A
PubMed ID10677502
Bcl2 phosphorylation at Ser-70 may be required for the full and potent suppression of apoptosis in IL-3-dependent myeloid cells and can result from agonist activation of mitochondrial protein kinase C (PKC). Paradoxically, expression of exogenous Bcl2 can protect parental cells from apoptosis induced by the potent PKC inhibitor, staurosporine (stauro). ... More