Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine.
AuthorsRing BJ, Eckstein JA, Gillespie JS, Binkley SN, VandenBranden M, Wrighton SA,
JournalJ Pharmacol Exp Ther
PubMed ID11356927
'The formation of R- and S-norfluoxetine was analyzed in vitro in human liver microsomes. Low apparent K(m) values for R-norfluoxetine formation of < or =8 microM and S-norfluoxetine of <0.2 microM were determined. R-Norfluoxetine formation rates in a characterized microsomal bank correlated with the catalytic activities for cytochrome P450 (CYP) ... More