PLC-gamma2 is essential for formation and maintenance of memory B cells.
AuthorsHikida M, Casola S, Takahashi N, Kaji T, Takemori T, Rajewsky K, Kurosaki T,
JournalJ Exp Med
PubMed ID19273623
Resting antigen-experienced memory B cells are thought to be responsible for the more rapid and robust antibody responses after antigen reencounter, which are the hallmark of memory humoral responses. The molecular basis for the development and survival of memory B cells remains largely unknown. We report that phospholipase C (PLC) ... More