The human papillomavirus type 16 E5 oncoprotein inhibits epidermal growth factor trafficking independently of endosome acidification.
AuthorsSuprynowicz FA, Krawczyk E, Hebert JD, Sudarshan SR, Simic V, Kamonjoh CM, Schlegel R,
JournalJ Virol
PubMed ID20686024
The human papillomavirus type 16 E5 oncoprotein (16E5) enhances acute, ligand-dependent activation of the epidermal growth factor receptor (EGFR) and concomitantly alkalinizes endosomes, presumably by binding to the 16-kDa ... More
A novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradation.
AuthorsZhang C, Li A, Zhang X, Xiao H,
JournalJ Biol Chem
PubMed ID21252234
Activated epidermal growth factor receptor (EGFR) continues to signal in the early endosome, but how this signaling process is regulated is less well understood. Here we describe a protein complex consisting of TIP30, endophilin B1, and acyl-CoA synthetase long chain family member 4 (ACSL4) that interacts with Rab5a and regulates ... More
EWI-2 controls nucleocytoplasmic shuttling of EGFR signaling molecules and miRNA sorting in exosomes to inhibit prostate cancer cell metastasis.
Authors
JournalMol Oncol
PubMed ID33605506
Culture and Nucleofection of Postnatal Day 7 Cortical and Cerebellar Mouse Astroglial Cells.